A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

• Asıl Yazarlar: Shai Berlin (Yazar), Etay Artzy (Yazar), Reem Handklo-Jamal (Yazar), Uri Kahanovitch (Yazar), Hanna Parnas (Yazar), Nathan Dascal (Yazar), Daniel Yakubovich (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GIRK...