A Dual-Functioning 5ʹ-PPP-NS1shRNA that Activates a RIG-I Antiviral Pathway and Suppresses Influenza NS1

• Main Authors: Neetu Singh (Author), Priya Ranjan (Author), Weiping Cao (Author), Jenish Patel (Author), Shivaprakash Gangappa (Author), Bruce A. Davidson (Author), John M. Sullivan (Author), Paras N. Prasad (Author), Paul R. Knight (Author), Suryaprakash Sambhara (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinoic acid-inducible gene-I (RIG-I) is a cytosolic pathogen sensor that is crucial against a number of viral infections. Many viruses have evolved to inhibit pathogen sensors to suppress host innate immune responses. In the case of influenza, nonstructural protein 1 (NS1) suppresses RIG-I functio...