Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

• Main Authors: Giselle A. Borges e Soares (Author), Tanima Bhattacharya (Author), Shivalingrao Mamledesai (Author), Zhaoquan Ai (Author), Alexandru Madalin Hasan (Author), Simona Cavalu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs....