Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

• Váldodahkkit: Giselle A. Borges e Soares (Dahkki), Tanima Bhattacharya (Dahkki), Shivalingrao Mamledesai (Dahkki), Zhaoquan Ai (Dahkki), Alexandru Madalin Hasan (Dahkki), Simona Cavalu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs....