Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

• Main Authors: Zheng-Quan Lai (Author), Siu-Po Ip (Author), Hui-Jun Liao (Author), Zheng Lu (Author), Jian-Hui Xie (Author), Zi-Ren Su (Author), Yun-Long Chen (Author), Yan-Fang Xian (Author), Po-Sing Leung (Author), Zhi-Xiu Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxi...