Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

• Κύριοι συγγραφείς: Zheng-Quan Lai (Συγγραφέας), Siu-Po Ip (Συγγραφέας), Hui-Jun Liao (Συγγραφέας), Zheng Lu (Συγγραφέας), Jian-Hui Xie (Συγγραφέας), Zi-Ren Su (Συγγραφέας), Yun-Long Chen (Συγγραφέας), Yan-Fang Xian (Συγγραφέας), Po-Sing Leung (Συγγραφέας), Zhi-Xiu Lin (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxi...