Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing

• Main Authors: Mojgan ATAEI-KACHOUEI (Author), Javad NADAF (Author), Mohammad Taghi AKBARI (Author), Morteza ATRI (Author), Jacek MAJEWSKI (Author), Yasser RIAZALHOSSEINI (Author), Masoud GARSHASBI (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Germ-line mutations of BRCA1 and BRCA2 genes are responsible for approximately 25-30% of dominantly inherited familial breast cancers; still a big part of genetic component is unknown. The aim of this study was to investigate genetic causes of familial breast cancer in a pedigree with re...