Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing

• Prif Awduron: Mojgan ATAEI-KACHOUEI (Awdur), Javad NADAF (Awdur), Mohammad Taghi AKBARI (Awdur), Morteza ATRI (Awdur), Jacek MAJEWSKI (Awdur), Yasser RIAZALHOSSEINI (Awdur), Masoud GARSHASBI (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Tehran University of Medical Sciences, 2015-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Background: Germ-line mutations of BRCA1 and BRCA2 genes are responsible for approximately 25-30% of dominantly inherited familial breast cancers; still a big part of genetic component is unknown. The aim of this study was to investigate genetic causes of familial breast cancer in a pedigree with re...