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Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme to...

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Príomhchruthaitheoirí:	Nada H. El-Dershaby (Údar), Soad A. El-Hawash (Údar), Shaymaa E. Kassab (Údar), Hoda G. Dabees (Údar), Ahmed E. Abdel Moneim (Údar), Ibrahim A. Abdel Wahab (Údar), Mohammad M. Abd-Alhaseeb (Údar), Mostafa M. M. El-Miligy (Údar)
Formáid:	LEABHAR
Foilsithe / Cruthaithe:	Taylor & Francis Group, 2022-12-01T00:00:00Z.
Ábhair:	article
Rochtain ar líne:	Connect to this object online.
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

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