Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection

• Main Authors: Myoung Jin Ho (Author), Hoe Taek Jeong (Author), Sung Hyun Im (Author), Hyung Tae Kim (Author), Jeong Eun Lee (Author), Jun Soo Park (Author), Ha Ra Cho (Author), Dong Yoon Kim (Author), Young Wook Choi (Author), Joon Woo Lee (Author), Yong Seok Choi (Author), Myung Joo Kang (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel polymeric microsphere (MS) containing micronized triamcinolone acetonide (TA) in a crystalline state was structured to provide extended drug retention in joints after intra-articular (IA) injection. Microcrystals with a median diameter of 1.7 μm were prepared by ultra-sonication met...