Folic Acid Improves Parkin-Null <i>Drosophila</i> Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium

• 主要な著者: Katherine L. Houlihan (著者), Petros P. Keoseyan (著者), Amber N. Juba (著者), Tigran Margaryan (著者), Max E. Voss (著者), Alexander M. Babaoghli (著者), Justin M. Norris (著者), Greg J. Adrian (著者), Artak Tovmasyan (著者), Lori M. Buhlman (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Loss-of-function parkin mutations cause oxidative stress and degeneration of dopaminergic neurons in the substantia nigra. Several consequences of parkin mutations have been described; to what degree they contribute to selective neurodegeneration remains unclear. Specific factors initiating excessiv...