Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels

• Main Authors: Maho Tsubota (Author), Tomoka Ozaki (Author), Yuko Hayashi (Author), Yasumasa Okawa (Author), Ayaka Fujimura (Author), Fumiko Sekiguchi (Author), Hiroyuki Nishikawa (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h af...