Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels

• Päätekijät: Maho Tsubota (Tekijä), Tomoka Ozaki (Tekijä), Yuko Hayashi (Tekijä), Yasumasa Okawa (Tekijä), Ayaka Fujimura (Tekijä), Fumiko Sekiguchi (Tekijä), Hiroyuki Nishikawa (Tekijä), Atsufumi Kawabata (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h af...