α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way

• Main Authors: Andrea Grandi (Author), Irene Zini (Author), Lisa Flammini (Author), Anna M. Cantoni (Author), Valentina Vivo (Author), Vigilio Ballabeni (Author), Elisabetta Barocelli (Author), Simona Bertoni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The existence of a cholinergic anti-inflammatory pathway negatively modulating the inflammatory and immune responses in various clinical conditions and experimental models has long been postulated. In particular, the protective involvement of the vagus nerve and of nicotinic Ach receptors (nAChRs) h...