Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

• Autori principali: Kevin McNally (Autore), Craig Sams (Autore), Alex Hogg (Autore), George Loizou (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the metabolism and biokinetics of DEHTP following a single oral dose of 50 mg to three male volunteers. In vitro and...