Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

• 主要な著者: Kevin McNally (著者), Craig Sams (著者), Alex Hogg (著者), George Loizou (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the metabolism and biokinetics of DEHTP following a single oral dose of 50 mg to three male volunteers. In vitro and...