SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles

• Glavni autori: Ignacio A. Gallardo (Autor), Daniel A. Todd (Autor), Stella T. Lima (Autor), Jonathan R. Chekan (Autor), Norman H. Chiu (Autor), Ethan Will Taylor (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2023-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Associations between dietary selenium status and the clinical outcome of many viral infections, including SARS-CoV-2, are well established. Multiple independent studies have documented a significant inverse correlation between selenium status and the incidence and mortality of COVID-19. At the molec...