Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma

• Main Authors: Cobbs Gary A (Author), Hein David W (Author), Doll Mark A (Author), Martini Benjamin D (Author), Crawford Nigel PS (Author), Colliver Daniel W (Author), Mahid Suhal S (Author), Petras Robert E (Author), Galandiuk Susan (Author)
• Format: Book
• Published: BMC, 2007-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to elec...