Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

• Principais autores: Xanthi Antoniou (Autor), Gianluigi Forloni (Autor), Monica Di Luca (Autor), Fabrizio Gardoni (Autor), Mariaelena Repici (Autor), Alessio Colombo (Autor), Alessandra Sclip (Autor), Cristina Ploia (Autor), Tiziana Borsello (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2010-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kinas...