Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy

• Asıl Yazarlar: Irene Pachón-Angona (Yazar), Bernard Refouvelet (Yazar), Rudolf Andrýs (Yazar), Helène Martin (Yazar), Vincent Luzet (Yazar), Isabel Iriepa (Yazar), Ignacio Moraleda (Yazar), Daniel Diez-Iriepa (Yazar), María-Jesú (Yazar), José Marco-Contelles (Yazar), Kamil Musilek (Yazar), Lhassane Ismaili (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC50 ...