Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy

• Main Authors: Irene Pachón-Angona (Author), Bernard Refouvelet (Author), Rudolf Andrýs (Author), Helène Martin (Author), Vincent Luzet (Author), Isabel Iriepa (Author), Ignacio Moraleda (Author), Daniel Diez-Iriepa (Author), María-Jesú (Author), José Marco-Contelles (Author), Kamil Musilek (Author), Lhassane Ismaili (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC50 ...