TLR2 Derangements Likely Play a Significant Role in the Inflammatory Response and Thrombosis in Patients with Ph(−) Classical Myeloproliferative Neoplasm

• Main Authors: Jen Chin Wang (Author), Guanfang Shi (Author), Chi Chen (Author), Ching Wong (Author), Vladimir Gotlieb (Author), Gardith Joseph (Author), Kiron V Nair (Author), Lakshmi Boyapati (Author), Enayati Ladan (Author), James T. Symanowski (Author), Lishi Sun (Author)
• Format: Book
• Published: Hindawi Limited, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the role of toll-like receptors (TLRs) in inflammatory pathways in Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(−)MPNs). TLR2 expression was increased in ET, PV, and MPN (grouped as (PV + (ET) + MF)), whereas TLR4 was elevated only in MPN. TLR3, 7, and 9 were not...