Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

• Main Authors: Marine Tournissac (Author), Philippe Bourassa (Author), Ruben D. Martinez-Cano (Author), Tra-My Vu (Author), Sébastien S. Hébert (Author), Emmanuel Planel (Author), Frédéric Calon (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces tau hyperphosphorylation. The 3xTg-AD mouse model not only develops tau and amyloid pathologies in the bra...