Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

• Autors principals: Marine Tournissac (Autor), Philippe Bourassa (Autor), Ruben D. Martinez-Cano (Autor), Tra-My Vu (Autor), Sébastien S. Hébert (Autor), Emmanuel Planel (Autor), Frédéric Calon (Autor)
• Format: Llibre
• Publicat: Elsevier, 2019-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces tau hyperphosphorylation. The 3xTg-AD mouse model not only develops tau and amyloid pathologies in the bra...