Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling

• Main Authors: Cheng-Hsun Lu (Author), Chieh-Yu Shen (Author), Ko-Jen Li (Author), Cheng-Han Wu (Author), Yu-Hsuan Chen (Author), Yu-Min Kuo (Author), Song-Chou Hsieh (Author), Chia-Li Yu (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and subsequent spontaneous remission within 7-10 days. Activated PMNs release neutrophil extracellular traps (NETs) that entrap MSU crystals, forming NET-MSU aggr...