IL-4 induces cAMP and cGMP in human monocytic cells

• Príomhchruthaitheoirí: B. Dugas (Údar), N. Paul-Eugene (Údar), K. Yamaoka (Údar), C. Amirand (Údar), C. Damais (Údar), J. P. Kolb (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Hindawi Limited, 1995-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Human monocytes, preincubated with IFN-γ respond to IL-4 by a cGMP increase through activation of an inducible NO synthase. Here, IL-4 was found to induce an accumulation of cGMP (1 - 3 min) and cAMP (20 - 25 min) in unstimulated monocytes. This was impaired with NOS inhibitors, but also with EGTA a...