IL-4 induces cAMP and cGMP in human monocytic cells

• Main Authors: B. Dugas (Author), N. Paul-Eugene (Author), K. Yamaoka (Author), C. Amirand (Author), C. Damais (Author), J. P. Kolb (Author)
• Format: Book
• Published: Hindawi Limited, 1995-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human monocytes, preincubated with IFN-γ respond to IL-4 by a cGMP increase through activation of an inducible NO synthase. Here, IL-4 was found to induce an accumulation of cGMP (1 - 3 min) and cAMP (20 - 25 min) in unstimulated monocytes. This was impaired with NOS inhibitors, but also with EGTA a...