Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation

• Autores principales: Zhen-Hai Shang (Autor), Yue-E Wu (Autor), Dong-Mei Lv (Autor), Wei Zhang (Autor), Wen-Qiang Liu (Autor), John van den Anker (Autor), Yan Xu (Autor), Wei Zhao (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objective: The perspective of real-world study is especially relevant to newborns, enabling dosage regimen optimization and regulatory approval of medications for use in newborns. The aim of the present study was to conduct a pharmacokinetic analysis of cefotaxime and evaluate the dosage used in new...