Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation

• Auteurs principaux: Zhen-Hai Shang (Auteur), Yue-E Wu (Auteur), Dong-Mei Lv (Auteur), Wei Zhang (Auteur), Wen-Qiang Liu (Auteur), John van den Anker (Auteur), Yan Xu (Auteur), Wei Zhao (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: The perspective of real-world study is especially relevant to newborns, enabling dosage regimen optimization and regulatory approval of medications for use in newborns. The aim of the present study was to conduct a pharmacokinetic analysis of cefotaxime and evaluate the dosage used in new...