Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation

• Main Authors: Zhen-Hai Shang (Author), Yue-E Wu (Author), Dong-Mei Lv (Author), Wei Zhang (Author), Wen-Qiang Liu (Author), John van den Anker (Author), Yan Xu (Author), Wei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The perspective of real-world study is especially relevant to newborns, enabling dosage regimen optimization and regulatory approval of medications for use in newborns. The aim of the present study was to conduct a pharmacokinetic analysis of cefotaxime and evaluate the dosage used in new...