The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

• Main Authors: Alice Melocchi (Author), Marco Uboldi (Author), Francesco Briatico-Vangosa (Author), Saliha Moutaharrik (Author), Matteo Cerea (Author), Anastasia Foppoli (Author), Alessandra Maroni (Author), Luca Palugan (Author), Lucia Zema (Author), Andrea Gazzaniga (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configurati...