Deletion of the App-Runx1 region in mice models human partial monosomy 21

• Prif Awduron: Thomas Arbogast (Awdur), Matthieu Raveau (Awdur), Claire Chevalier (Awdur), Valérie Nalesso (Awdur), Doulaye Dembele (Awdur), Hugues Jacobs (Awdur), Olivia Wendling (Awdur), Michel Roux (Awdur), Arnaud Duchon (Awdur), Yann Herault (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: The Company of Biologists, 2015-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Partial monosomy 21 (PM21) is a rare chromosomal abnormality that is characterized by the loss of a variable segment along human chromosome 21 (Hsa21). The clinical phenotypes of this loss are heterogeneous and range from mild alterations to lethal consequences, depending on the affected region of H...