Deletion of the App-Runx1 region in mice models human partial monosomy 21

Partial monosomy 21 (PM21) is a rare chromosomal abnormality that is characterized by the loss of a variable segment along human chromosome 21 (Hsa21). The clinical phenotypes of this loss are heterogeneous and range from mild alterations to lethal consequences, depending on the affected region of H...

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Main Authors: Thomas Arbogast (Author), Matthieu Raveau (Author), Claire Chevalier (Author), Valérie Nalesso (Author), Doulaye Dembele (Author), Hugues Jacobs (Author), Olivia Wendling (Author), Michel Roux (Author), Arnaud Duchon (Author), Yann Herault (Author)
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Publicado em: The Company of Biologists, 2015-06-01T00:00:00Z.
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