Shaping the "hot" immunogenic tumor microenvironment by nanoparticles co‐delivering oncolytic peptide and TGF‐β1 siRNA for boosting checkpoint blockade therapy

• Main Authors: Cao Dai Phung (Author), Bao Loc Nguyen (Author), Jee‐Heon Jeong (Author), Jae‐Hoon Chang (Author), Sung Giu Jin (Author), Han‐Gon Choi (Author), Sae Kwang Ku (Author), Jong Oh Kim (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Induction of potent immune responses toward tumors remains challenging in cancer immunotherapy, in which it only showed benefits in a minority of patients with "hot" tumors, which possess pre‐existing effector immune cells within the tumor. In this study, we proposed a nanoparticl...