Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

• Κύριοι συγγραφείς: Isak W. Tengesdal (Συγγραφέας), Suzhao Li (Συγγραφέας), Nicholas E. Powers (Συγγραφέας), Makenna May (Συγγραφέας), Charles P. Neff (Συγγραφέας), Leo A. B. Joosten (Συγγραφέας), Carlo Marchetti (Συγγραφέας), Charles A. Dinarello (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-05-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microe...