Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

• Hoofdauteurs: Isak W. Tengesdal (Auteur), Suzhao Li (Auteur), Nicholas E. Powers (Auteur), Makenna May (Auteur), Charles P. Neff (Auteur), Leo A. B. Joosten (Auteur), Carlo Marchetti (Auteur), Charles A. Dinarello (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microe...