Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

• Main Authors: Isak W. Tengesdal (Author), Suzhao Li (Author), Nicholas E. Powers (Author), Makenna May (Author), Charles P. Neff (Author), Leo A. B. Joosten (Author), Carlo Marchetti (Author), Charles A. Dinarello (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microe...