Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

• Autores principales: Isak W. Tengesdal (Autor), Suzhao Li (Autor), Nicholas E. Powers (Autor), Makenna May (Autor), Charles P. Neff (Autor), Leo A. B. Joosten (Autor), Carlo Marchetti (Autor), Charles A. Dinarello (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microe...