A systematic in vitro investigation on poly-arginine modified nanostructured lipid carrier: Pharmaceutical characteristics, cellular uptake, mechanisms and cytotoxicity

• Главные авторы: Mingshuang Sun (Автор), Yunyun Gao (Автор), Zhihong Zhu (Автор), Huixin Wang (Автор), Cuiyan Han (Автор), Xinggang Yang (Автор), Weisan Pan (Автор)
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• Опубликовано: Elsevier, 2017-01-01T00:00:00Z.
• Предметы: article
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The aim of the present study was to develop a poly-arginine modified nanostructured lipid carrier (R-NLC) by fusion-emulsification method and to test its pharmaceutical characteristics. The influence of R-NLC on A549 cells like cellular uptake and cytotoxicity was also appraised using unmodified NLC...