Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

• मुख्य लेखकों: Celina de Jesus Guimarães (लेखक), Teiliane Rodrigues Carneiro (लेखक), Marisa Jadna Silva Frederico (लेखक), Guilherme G. C. de Carvalho (लेखक), Matthew Little (लेखक), Valder N. Freire (लेखक), Victor L. B. França (लेखक), Daniel Nascimento do Amaral (लेखक), Jéssica de Siqueira Guedes (लेखक), Eliezer J. Barreiro (लेखक), Lídia Moreira Lima (लेखक), Francisco W. A. Barros-Nepomuceno (लेखक), Claudia Pessoa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated, yielding IC₅₀ values of...