Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

• Main Authors: Celina de Jesus Guimarães (Author), Teiliane Rodrigues Carneiro (Author), Marisa Jadna Silva Frederico (Author), Guilherme G. C. de Carvalho (Author), Matthew Little (Author), Valder N. Freire (Author), Victor L. B. França (Author), Daniel Nascimento do Amaral (Author), Jéssica de Siqueira Guedes (Author), Eliezer J. Barreiro (Author), Lídia Moreira Lima (Author), Francisco W. A. Barros-Nepomuceno (Author), Claudia Pessoa (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated, yielding IC₅₀ values of...