Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment

• Main Authors: Ruijie Yang (Author), Tianli Pei (Author), Ruifei Huang (Author), Yue Xiao (Author), Jiangna Yan (Author), Jinglin Zhu (Author), Chunli Zheng (Author), Wei Xiao (Author), Chao Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the tumor microenvironment (TME), the activation of programmed death-1 (PD-1)-programmed death ligand-1 (PD-L1) pathway is one of the main signals of immune escape and tumor deterioration. Clinically, the application of monoclonal antibodies slows down the progression of various malignancies and...