Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

• Main Authors: Ji-Won Hwang (Author), Jae-Hyun Park (Author), Bong-Woo Park (Author), Hyeok Kim (Author), Jin-Ju Kim (Author), Woo-Sup Sim (Author), Natalia P. Mishchenko (Author), Sergey A. Fedoreyev (Author), Elena A. Vasileva (Author), Kiwon Ban (Author), Hun-Jun Park (Author), Sang-Hong Baek (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reactive oxygen species (ROS) and intracellular iron levels are critical modulators of lipid peroxidation that trigger iron-dependent non-apoptotic ferroptosis in myocardial ischemia-reperfusion (I/R) injury. Histochrome (HC), with a potent antioxidant moiety and iron-chelating capacity, is now avai...