Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

• Hlavní autoři: Ji-Won Hwang (Autor), Jae-Hyun Park (Autor), Bong-Woo Park (Autor), Hyeok Kim (Autor), Jin-Ju Kim (Autor), Woo-Sup Sim (Autor), Natalia P. Mishchenko (Autor), Sergey A. Fedoreyev (Autor), Elena A. Vasileva (Autor), Kiwon Ban (Autor), Hun-Jun Park (Autor), Sang-Hong Baek (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2021-10-01T00:00:00Z.
• Témata: article
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Reactive oxygen species (ROS) and intracellular iron levels are critical modulators of lipid peroxidation that trigger iron-dependent non-apoptotic ferroptosis in myocardial ischemia-reperfusion (I/R) injury. Histochrome (HC), with a potent antioxidant moiety and iron-chelating capacity, is now avai...