NQO1 Binds and Supports SIRT1 Function

• Main Authors: Peter Tsvetkov (Author), Julia Adler (Author), Romano Strobelt (Author), Yaarit Adamovich (Author), Gad Asher (Author), Nina Reuven (Author), Yosef Shaul (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silent information regulator 2-related enzyme 1 (SIRT1) is an NAD+-dependent class III deacetylase and a key component of the cellular metabolic sensing pathway. The requirement of NAD+ for SIRT1 activity led us to assume that NQO1, an NADH oxidoreductase producing NAD+, regulates SIRT1 activity. We...