Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects

• मुख्य लेखकों: Jiuhong Zha (लेखक), Qi Jiang (लेखक), Betty B. Yao (लेखक), Daniel E. Cohen (लेखक), David C. Carter (लेखक), Rajeev M. Menon (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The immunosuppressive agents sirolimus and everolimus are sensitive CYP3A4 substrates with narrow therapeutic index. Ritonavir is a strong CYP3A inhibitor. A phase 1 study was conducted to evaluate the pharmacokinetics, safety, and tolerability of the co‐administration of sirolimus or evero...