Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects

• Glavni autori: Jiuhong Zha (Autor), Qi Jiang (Autor), Betty B. Yao (Autor), Daniel E. Cohen (Autor), David C. Carter (Autor), Rajeev M. Menon (Autor)
• Format: Knjiga
• Izdano: Wiley, 2022-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract The immunosuppressive agents sirolimus and everolimus are sensitive CYP3A4 substrates with narrow therapeutic index. Ritonavir is a strong CYP3A inhibitor. A phase 1 study was conducted to evaluate the pharmacokinetics, safety, and tolerability of the co‐administration of sirolimus or evero...