Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L

• Main Authors: Amanda Fernandes de Medeiros (Author), Beatriz Blenda Pinheiro de Souza (Author), Lucas Pinheiro Coutinho (Author), Aline Melro Murad (Author), Paula Ivani Medeiros dos Santos (Author), Norberto de Kássio Vieira Monteiro (Author), Elizeu Antunes dos Santos (Author), Bruna Leal Lima Maciel (Author), Ana Heloneida de Araújo Morais (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypsin inhibitors from tamarind seed have been studied in vitro and in preclinical studies for the treatment of obesity, its complications and associated comorbidities. It is still necessary to fully understand the structure and behaviour of these molecules. We purifed this inhibitor, sequenced de...