Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

• Main Authors: Cassandra Chaptini, MBBS (Author), Genevieve Casey, MBBS (Author), Adam G. Harris, MBChB (Author), David Wattchow, FRACS (Author), Lynne Gordon, FACD (Author), Dedee F. Murrell, MA, BMBCh, FAAD, MD, FACD, FRCP (Author)
• Format: Book
• Published: Wolters Kluwer, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter...