Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

• Main Authors: Alesia V. Prakapenka (Author), Veronica L. Peña (Author), Isabel Strouse (Author), Steven Northup-Smith (Author), Ally Schrier (Author), Kinza Ahmed (Author), Heather A. Bimonte-Nelson (Author), Rachael W. Sirianni (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exogenously administered 17β-estradiol (E2) can improve spatial learning and memory, although E2 also exerts undesired effects on peripheral organs. Clinically, E2 has been solubilized in cyclodextrin for intranasal administration, which enhances brain-specific delivery. Prior work shows that the cy...