Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

• প্রধান লেখক: Alesia V. Prakapenka (লেখক), Veronica L. Peña (লেখক), Isabel Strouse (লেখক), Steven Northup-Smith (লেখক), Ally Schrier (লেখক), Kinza Ahmed (লেখক), Heather A. Bimonte-Nelson (লেখক), Rachael W. Sirianni (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2020-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Exogenously administered 17β-estradiol (E2) can improve spatial learning and memory, although E2 also exerts undesired effects on peripheral organs. Clinically, E2 has been solubilized in cyclodextrin for intranasal administration, which enhances brain-specific delivery. Prior work shows that the cy...