Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds

• Main Authors: Mandula Borjigin (Author), Bryan Strouse (Author), Rohina A Niamat (Author), Pawel Bialk (Author), Chris Eskridge (Author), Jingwei Xie (Author), Eric B Kmiec (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene editing is a process by which single base mutations can be corrected, in the context of the chromosome, using single-stranded oligodeoxynucleotides (ssODNs). The survival and proliferation of the corrected cells bearing modified genes, however, are impeded by a phenomenon known as reduced proli...