Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

• 主要な著者: Xiaohua Liu (著者), Yu Zhang (著者), Yalei Li (著者), Juan Wang (著者), Huaqian Ding (著者), Wenjing Huang (著者), Chunyong Ding (著者), Hongchun Liu (著者), Wenfu Tan (著者), Ao Zhang (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2021-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional factors GLI through bromodomain-containing protein 4 (...