Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

• Main Authors: Xiaohua Liu (Author), Yu Zhang (Author), Yalei Li (Author), Juan Wang (Author), Huaqian Ding (Author), Wenjing Huang (Author), Chunyong Ding (Author), Hongchun Liu (Author), Wenfu Tan (Author), Ao Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional factors GLI through bromodomain-containing protein 4 (...