Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

• Hoofdauteurs: Xiaohua Liu (Auteur), Yu Zhang (Auteur), Yalei Li (Auteur), Juan Wang (Auteur), Huaqian Ding (Auteur), Wenjing Huang (Auteur), Chunyong Ding (Auteur), Hongchun Liu (Auteur), Wenfu Tan (Auteur), Ao Zhang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2021-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Medulloblastoma (MB) is a common yet highly heterogeneous childhood malignant brain tumor, however, clinically effective molecular targeted therapy is lacking. Modulation of hedgehog (HH) signaling by epigenetically targeting the transcriptional factors GLI through bromodomain-containing protein 4 (...