NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

• Váldodahkkit: Laila R.B. Santos (Dahkki), Carole Muller (Dahkki), Arnaldo H. de Souza (Dahkki), Hilton K. Takahashi (Dahkki), Peter Spégel (Dahkki), Ian R. Sweet (Dahkki), Heeyoung Chae (Dahkki), Hindrik Mulder (Dahkki), Jean-Christophe Jonas (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2017-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH at the expense of NADH and ΔpH in energized mitochon...