NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

• Main Authors: Laila R.B. Santos (Author), Carole Muller (Author), Arnaldo H. de Souza (Author), Hilton K. Takahashi (Author), Peter Spégel (Author), Ian R. Sweet (Author), Heeyoung Chae (Author), Hindrik Mulder (Author), Jean-Christophe Jonas (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH at the expense of NADH and ΔpH in energized mitochon...